TAXINOMISIS

Μultidisciplinary approach
stratification of patients with carotid artery disease

TAXINOMISIS is a European Commission funded research project which aims to develop a new approach for the stratification of carotid artery disease patients.
TAXINOMISIS takes bold step beyond the state of the art unwinding the pathobiology underlying symptomatic plaques, discriminating distinct disease mechanism-driven states and biomarkers, and developing a multiscale risk stratification model.
TAXINOMISIS will deliver, as a main outcome, a software platform, which can perform the risk stratification.

TAXINOMISIS innovation capacity

Purpose

Provide novel disease mechanism-based stratification for carotid artery disease patients to address the need for stratified and personalised therapeutic interventions in the current era.

Purpose

Investigate the causal relationship of the major pathways and factors identified in symptomatic carotid artery disease
Study disease phenotypes and disintegrate them into endotypes according to specific pathobiological mechanisms
Integrate a computational model and an agent based model of plaque progression in the risk stratification tool
Perform a test for determining the presence of single Nucleotide Polymorphisms and predicting drug response
Evaluate the risk model of carotid artery disease stratification in an observational multicentre clinical study
Present a cost-effectiveness analysis

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 755320.

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The overall purpose of TAXINOMISIS is to provide novel disease mechanism-based stratification for carotid artery disease patients to address the need for stratified and personalised therapeutic interventions in the current era.

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